The difference is that tioguanine replaces a hydrogen with an amine group. What would be the effect of replacing the hydrogen on the smaller ring of mercaptopurine with an amine group? Or a methyl group?
Answering those questions could lead to a new leukemia medicine.
Rotating molecules so that the main features point in the same direction can offer insights. It's easier to do that with ball and stick models.
I wonder about the effects of replacing the double-bonded oxygens with sulfur in the above molecules.
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