Allopurinol has a double-bonded oxygen vs a double-bonded sulfur in mercaptopurine. Allopurinol also lacks a nitrogen-carbon double bond in its smaller ring. Basically, mercaptopurine has two nitrogen-hydrogen bonds on its smaller ring while allopurinol has one nitrogen-hydrogen bond on its larger ring and one on its smaller wing. Also, there is a carbon atom between the two nitrogen atoms in the smaller ring of allopurinol. My questions are:
Could substituting sulfur for oxygen on allopurinol create a new leukemia medicine?
What would be the effects changing the double bonds on mercaptopurine to be the same as allopurinol?
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