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Thursday, November 30, 2023

My CIA Memento

In 2002, I got an award from the CIA for a science fair project in which I built a miniature radio transmitter. I was invited to the headquarters in Langley, went on a tour, and got some cool souvenirs, including quick-dissolving paper that was also edible. 



Thursday, November 23, 2023

A Short Case Against a Conspiracy to Assassinate JFK

I admit to having been skeptical of the official explanation. The main reasons for that were Oswald's quick death at the hands of Ruby and the assassination coming so soon after JFK fired Dulles, then CIA director and popular among DC elites. 

Then I learned about Oswald's assassination attempt on General Walker a mere seven months before killing JFK. 

If the CIA failed in its many attempts to kill Castro, a much easier target, I hardly expect they would have had much success in a plot to kill JFK. And the fact that the FBI left Oswald alone after he defected to the USSR and returned to the US also points to simple incompetence. 

In a similar way, when I read about how the 9/11 hijackers were able to get visas despite submitting shoddy paperwork, that too reinforces the laziness/incompetence explanation for the failure of the US government to thwart that attack.

In fact, the visas for the Saudi hijackers were initially denied, but that decision was overruled by another official named Shayna Steinger. She later testified to Congress about her actions, and amazingly, continued to be promoted. Also, the official who initially denied the applications got fired. 

Elsewhere, I found this from Keeping Terror Out (cis.org)

***
A normal level of visa scrutiny, for instance, would have excluded almost all the hijackers. Investigative reporter Joel Mowbray acquired copies of 15 of the 19 hijackers' visa applications (the other four were destroyed - yes, destroyed - by the State Department), and every one of the half-dozen current and former consular officers he consulted said every application should have been rejected on its face. Every application was incomplete or contained patently inadequate or absurd answers.
***

I can say from personal experience that bureaucrats are often selectively scrupulous about paperwork, and they can move fast if they want to. 

This article had some darkly amusing gems: State Dept. Lapses Aided 9/11 Hijackers - ABC News (go.com)

***
Brothers Wail and Waleed al Shehri applied together in October 2000. Under "occupation" Wail wrote "teater;" brother Waleed claimed "student." The name and address of alleged employer and school was listed as "South City," and the questionable U.S. destination named as "Wasantwn."

Visas approved.

Abdulaziz Alomari claimed to be a student but didn't name a school; claimed to be married but didn't name a spouse; under nationality and gender, he didn't list anything.

Visa approved.

Three months later, Alomari followed his friend Mohamed Atta through airport security … heading for the World Trade Center.

Khalid Al Mihdhar, who helped crash the plane into the Pentagon, simply listed "Hotel" as his U.S. destination — no name, no city, no state — but no problem getting a visa.
***

I read things like this, and it makes me wonder why I ever bothered to fill out a government form completely or honestly or at all. 

On a side note, "Wasantwn" is very close to the way "Washington" would be spelled with the equivalent Arabic letters. (waw-sheen-noon-taw-waw-noon). 

Tuesday, November 21, 2023

Mathematical Evidence for Massive Fraud in the 2020 Election

The first red flag is that Trump won Ohio and Florida, but somehow lost the election. That hasn't happened since 1960. Here I will note that fewer than 100,000 votes out of 69 million cast decided the outcome of that election. That's a margin of 0.14%. So already we're in blizzard-in-Texas-in-July levels of improbability. Check this out: Biden supposedly won Pennsylvania and Michigan by a margin of about 100,000 votes. Those were two of the three states that propelled Trump to victory in 2016. 

Turning once more to Wikipedia, which is often more reliable than its critics allege, I find that in 2016:

***
the election hinged not on Clinton's large 2.8 million overall vote margin over Trump, but rather on about 78,000 votes from only three counties in Wisconsin, Pennsylvania, and Michigan.
***

I assure you Team Blue election strategists made note of this and spent the next four years devising countermeasures. Hint: each of those states have a big city that leans Democrat. Back to 2020:

***
The election saw the highest voter turnout by percentage since 1900, with each of the two main tickets receiving more than 74 million votes, surpassing Barack Obama's record of 69.5 million votes from 2008. Biden received more than 81 million votes...
***

Those stats are the next two red flags. Really? Biden more popular than Obama? Biden, he of two failed presidential campaigns? The same Biden who lost the first two primaries?

***
Biden became the first Democratic candidate since Bill Clinton, and the third ever Democratic candidate, to win the nomination without carrying either Iowa or New Hampshire, the first two states on the primary/caucus calendar.
***

***
Biden also became the first Democrat to win a presidential election in Georgia since 1992, in Arizona since 1996, and in Nebraska's 2nd congressional district since 2008.
***

And there's the 2020 postal vote tally:

***
A record number of voters, in excess of 65.6 million, cast postal votes.
***

Red flag #6. In person voting is the only way to verify that the name on the ballot is the same as the person who actually cast it. Dead people vote in every election, and it's even easier for them to vote by mail. For this reason and others, most countries do not allow postal voting and most of the rest only allow it in certain cases. Here's map:


***
Although Trump had won the state in 2016 by a narrow margin of 0.72%, Biden was able to reclaim the state, winning it by a similarly narrow 1.17% margin. Because of the way the state counted in-person ballots first, Trump started with a wide lead on election night. However, over the next few days, Biden greatly closed the margin due to outstanding votes from Democratic-leaning areas, most notably Philadelphia and Pittsburgh, as well as mail-in ballots from all parts of the state which strongly favored him.
***

OK, we know have enough red flags for a May Day parade. But maybe you're still not convinced. 

Politico wrote:

***
Democrats return nearly three times as many mail-in ballots as Republicans in Pennsylvania
***

None of these things by themselves prove fraud, but it looks mighty suspicious to me. 

The War In Ukraine as a Political Smokescreen, or Wag the Dog 2, Warmonger Boogaloo

First, some background is needed.  

From Wikipedia

***
Frank Giustra donated $31.3 million to the Clinton Foundation, to be followed in 2007 with a pledge of at least $100 million. 
...
Since uranium is considered a strategic asset with national security implications and Uranium One owned uranium mining operations in the United States, the acquisition of Uranium One by Rosatom was reviewed by the Committee on Foreign Investment in the United States (CFIUS), a committee of nine government cabinet departments and agencies including the United States Department of State, which was then headed by Hillary Clinton. 
...
On June 29, 2010, Renaissance Capital, a Russian investment bank with ties to the Kremlin and which was promoting Uranium One stock, paid Bill Clinton $500,000 for a speech in Moscow shortly after the Rosatom acquisition of Uranium One was announced.
***
.
Sounds sketchy as hell, right? Yet FactCheck.org reports this:

***
It may be that individuals and companies sought to curry favor with Hillary Clinton and even influence her department’s decision on the Uranium One sale. But, as we’ve written before, there is no evidence that donations to the Clinton Foundation from people with ties to Uranium One or Bill Clinton’s speaking fee influenced Hillary Clinton’s official actions.
***

Oh, blow me, you shameless political prostitutes. What a miserable heap of weasel words.

And then there's this gem from Len Bilen's beautiful blog:

***
Uranium is the feed-stock for nuclear power. It is also the material necessary to make nuclear bombs and making isotopes for medicinal and industrial uses.

The United States has 245,000 tons of Uranium reserves recoverable at less than $100 per kilogram, 1.9% of the world total. The price of uranium oxide is today about $80 per kilogram. This is about 12.5 years worth of domestic production, and as the great conservationist Sarah Palin used to quip, “when it is gone, it’s gone.”

The United States has, as of 2019, mined 444,500 tons of Uranium, or about 13% of the world total.

The United States consumed in 2019 19,570 tons of Uranium, about 23% of the world total, about 99.6% of which was imported. This is a great strategic vulnerability.

Which brings up the following question: Why did the Obama administration sell 20% of our proven reserves of this strategically important material to Russia?

It is of utmost importance to immediately restart the development of nuclear reactors that use Thorium as its feed-stock. Uranium based nuclear power can never fill our long term energy needs
***

Why, indeed. Turning to a "fact check" from The McPaper of Record:

***
It's true that Joe Biden leveraged $1 billion in aid to persuade Ukraine to oust its top prosecutor, Viktor Shokin, in March 2016. But it wasn't because Shokin was investigating Burisma. It was because Shokin wasn't pursuing corruption among the country's politicians.
***

And who was on the board of Burisma at that time? That's right, Joe Biden's crackhead son, Hunter Biden.



You know what would be a great way to cover all this up? A war between Russia and Ukraine. The demonization of Russia by US media serves to distract from the crooked deals the Clintons made under the auspices of Obama and Biden. It also distracts from the incompetence of Obama's diplomacy. 'Member Hillary's mistranslated reset button? I 'member. Meanwhile, the Ukrainians are too busy fighting the war to do any of their own investigating. It's the political equivalent of Dale Gribble yelling "pocket sand!" as he throws a handful in the eyes of his enemy and flees. 

Hillary blaming her 2016 loss on Russia also fits into this. How could she be dealing with Russians when they were fighting tooth and nail to sabotage her rightful ascension to the iron throne? 

And then there's this:

***
On October 7, 2016, the United States Department of Homeland Security and the Office of the Director of National Intelligence stated that the US intelligence community was "confident" that the Russian government directed the breaches and the release of the obtained or allegedly obtained material in an attempt to "... interfere with the US election process."
...
On October 7, 2016, one month before the United States presidential election, The Washington Post published a video and accompanying article about then-presidential candidate Donald Trump and television host Billy Bush having "an extremely lewd conversation about women" in September 2005.
***

The. same. fucking. day. Timing like this is not coincidental. The first story was meant to discredit emails leaked a few months prior and the second story was meant to establish the new narrative before amplifying it. 

That day was a Friday, the traditional day for dumping news. 

From PoliticalDictionary.com:

***
Releasing bad news or documents on a Friday afternoon in an attempt to avoid media scrutiny is often called a “Friday news dump” by members of the media.

This timing is often chosen strategically, aiming to minimize media coverage, public attention, and potential scrutiny that may arise from the news being released.

Often, the White House sets the release of bad news and unflattering documents to late Friday afternoon. The Pentagon and other agencies also use the practice, a legacy of earlier administrations.

Various types of information can be subject to a Friday news dump, including policy changes, government reports, legal documents, internal memos, or even personal disclosures.

This tactic has been employed by politicians, government agencies, corporations, or other entities seeking to manage the timing and perception of significant news developments.
***

Joe Biden's Voting Record as a Senator

Suggested music: Entry of the Gladiators




From Wikipedia:

***
From Jan 1973 to Jan 2009, Biden missed 1,781 of 14,556 roll call votes, which is 12.2%. This is much worse than the median of 2.0%

He played a key role in passing the Comprehensive Crime Control Act of 1984, which was controversial for several “tough-on-crime” provisions. He later expressed regret over this. Biden voted to ban homosexuals from serving in the military and to bar the federal government from recognizing same-sex marriages.

He voted against authorizing the First Gulf War, saying the US was bearing almost all the burden in the anti-Iraq coalition.

As chairman of the Senate Foreign Relations Committee he assembled witnesses who grossly misrepresented Saddam Hussein, his government and claimed possession of WMDs. Later he regretted his support for the Iraq War.

In 1984, he was a Democratic floor manager for the successful passage of the Comprehensive Crime Control Act. Over time, the law’s tough-on-crime provisions became controversial on the left and among criminal justice reform proponents, and in 2019 Biden called his role in passing the legislation a “big mistake”.

In 1993, Biden voted in favor of 10 U.S.C. §654, a section of a broader federally mandated policy that deemed homosexuality incompatible with military life thereby banning gay Americans from serving in the United States armed forces in any capacity without exception.

In 1996, Biden voted in favor of the Defense of Marriage Act (1 U.S.C. §7), which prohibited the federal government from recognizing any same-sex marriage, barring individuals in such marriages from equal protection under federal law, and allowing states to do the same.

Biden spoke to the auditorium and said his position on school busing was evolving, emphasizing that busing in Delaware was in his opinion beyond court restrictions. The crowd was unconvinced, and heckled him until he yielded the microphone.

In the Thomas hearings, Biden’s questions on constitutional issues were often long and convoluted, to the point that Thomas sometimes forgot the question being asked.[79] Biden’s style annoyed many viewers.

Biden was critical of the actions of Independent Counsel Kenneth Starr during the 1990s Whitewater controversy and Lewinsky scandal investigations, and said, “it’s going to be a cold day in hell” before another Independent Counsel would be granted the same powers.

As chairman of the International Narcotics Control Caucus, Biden wrote the laws that created the U.S. “Drug Czar”, who oversees and coordinates national drug control policy.

Once the Bosnian War broke out, Biden was among the first to call for the “lift and strike” policy of lifting the arms embargo, training Bosnian Muslims and supporting them with NATO air strikes…

In 1998, Congressional Quarterly named Biden one of “Twelve Who Made a Difference” for playing a lead role in several foreign policy matters, including NATO enlargement…

As head of the Senate Foreign Relations Committee, Biden said in 2002 that Saddam Hussein was a threat to national security and there was no option but to “eliminate” that threat.[112] In October 2002, he voted in favor of the Authorization for Use of Military Force Against Iraq, approving the U.S. invasion of Iraq.[96] More significantly, as chair of the committee, he assembled a series of witnesses to testify in favor of the authorization. They gave testimony misrepresenting the intent, history and status of Saddam and his Sunni government, which was an openly avowed enemy of al-Qaida, and touting Iraq’s possession of weapons of mass destruction.[113]
While he eventually became a critic of the war and viewed his vote and role as a “mistake”, he did not push for U.S. withdrawal.

Biden instead advocated dividing Iraq into a loose federation of three ethnic states.
Iraq’s political leadership denounced the resolution as de facto partitioning of the country, and the U.S. Embassy in Baghdad issued a statement distancing itself from it.

In May 2008, Biden sharply criticized President George W. Bush for his speech to Israel’s Knesset, where he suggested some Democrats were acting the way some Western leaders did when they appeased Hitler in the run-up to World War II. Biden said, “This is bullshit. This is malarkey. This is outrageous. Outrageous for the president of the United States to go to a foreign country, sit in the Knesset … and make this kind of ridiculous statement…

He allowed an amendment to the bill to increase the homestead exemption for homeowners declaring bankruptcy and fought for an amendment to forbid anti-abortion felons from using bankruptcy to discharge fines;

Biden held up trade agreements with Russia when that country stopped importing U.S. chickens. The downstate Sussex County region is the nation’s top chicken-producing area.

The New York Times wrote that Biden’s “weak filters make him capable of blurting out pretty much anything”
***

Jesus H tap-dancing, titty-fucking Christ in a goddamn chicken bucket. What a shithead!

Comparison of atropine and other heterocyclic compounds with one methylated nitrogen

Of the molecules shown below, atropine is the only one where nitrogen does not lie in the same plane as the other atoms of its ring. I don't know what the significance of that is. 















Monday, November 20, 2023

Regolith Elegy

Hard landing 
Lunar module damaged
My radio still crackles
I call Houston
No answer

I find Billy in the wreckage
I try to wake him
He's dead
I go out, plant the flag, and salute it
No one else will ever see that moment

I take Billy out and lay him down next to the flag
He would have wanted that
I survey the module from the outside
No way to take off again

Just enough oxygen left
To enjoy the view 
And write this poem
Goodbye, Earth
God bless America



My Old House in Tanzania

 


My house is the one on the left. I liked it. It had a concrete floor, metal roof, three bedrooms, a bathroom, a living room, and a kitchen. I had running water and electricity most of the time. Otherwise, I had candles and a few buckets of water I filled at a nearby pump.

Below are some pics of the chicken coop I built. I sawed all the planks myself. I also tried my hand at banana farming. I had better luck with that than raising chickens. 







Saturday, November 18, 2023

Ending World Hunger with Pasta, Ugali, or Sadza made from Jerusalem Artichoke Flour? Also, Atomic Survival Bread!

First, a recipe for bread from a survivor of the Yugoslav Wars. She calls it atomic bread. Easy to make and stays edible for a long time. 

Bing says

***

The cost of ending world hunger is a complex issue and depends on various factors. According to a study backed by the German government, ending hunger by 2030 would come with a price tag of $330 billion. The study suggests that by targeting enhanced aid money more effectively and with greater innovation, a solution is possible. International donors would need to add another $14 billion a year to their spending on food security and nutrition over the next 10 years; more than twice their current contribution. Low and middle-income countries would also have to give another $19 billion a year, potentially through taxation.

However, the United Nations has suggested that just $160 per year for each person living in extreme poverty would eradicate world hunger by 2030. The money should be delivered through both cash transfers and “pro-poor” investments

***

GlobalGiving says:

***

Estimates of how much money it would take to end world hunger range from $7 billion to $265 billion per year.  

Why such a big range? Because experts disagree about how to end world hunger. Hunger has many causes:

Bad weather

Disease outbreaks

Pests

War

Falling prices for crops

Rising prices for food

Low wages or unemployment 

No single solution can address them all. 

***

Greater cultivation of the Jerusalem artichoke could help:

***

The tubers can be eaten raw, cooked, or pickled.[9]

Before the arrival of Europeans, indigenous peoples cultivated H. tuberosus as a food source. The tubers persist for years after being planted, so the species expanded its range from central North America to the eastern and western regions.[citation needed] Early European colonists learned of this and sent tubers back to Europe, where they became a popular crop and naturalized there. It later gradually fell into obscurity in North America, but attempts to market it commercially were successful in the late 1900s and early 2000s.[7][10]

The tuber contains about 2% protein, no oil, and little starch.

...

Jerusalem artichokes have 650 mg potassium per 1 cup (150 g) serving. They are also high in iron and contain 10–12% of the USRDA of fiber, niacin, thiamine, phosphorus, and copper.[53]

***

It's tolerant of a wide range of conditions, easy to grow, and nutritious. It can also be preserved for long periods. 

The different types of hunger need to be considered. Is it being caused by a lack of calories, a lack of nutrients, or both?

WHO says:

***

Iodine, vitamin A, and iron are the most important in global public health terms; their deficiency represents a major threat to the health and development of populations worldwide, particularly children and pregnant women in low-income countries.

***

Vitamins D and B12 are also noteworthy in this category.

Ugali, also called sadza and many other names, is a corn porridge eaten in many countries afflicted by chronic hunger. While it is cheap and filling, it is somewhat low in calories and nutrients. It is usually eaten with beans or vegetables. 

It is possible to make flour with Jerusalem artichokes. That flour could be used to make ugali or sadza. I've also seen recipes where it is used to make pasta. I've never eaten Jerusalem artichokes myself, though it seems they taste like potatoes. 

On the other hand, the inulin in Jerusalem artichokes can cause flatulence. That's not really any worse than what happens with various beans though. 

Overclocking, Beowulf Clusters, Transformers, and Mineral Oil Cooling

Overclocking, cluster computing, and mineral oil cooling are not new ideas, yet they rarely have been combined. Let's look at some examples:

This is the top result on YouTube for the search "world's cheapest supercomputer":


It's an air-cooled GPU cluster in Japan. It had a lot of bang for the buck at the time, but there was no attempt to overclock it or use mineral oil cooling.

This Raspberry Pi cluster by Oracle only needs oil cooling and overclocking to be a real mean machine:


Mineral oil is cheap, non-toxic, non-conducting, and does not evaporate. It also has much better heat transfer properties. It's been used for a long time to cool high voltage transformers. Here is a brief history from: Mineral oils | Transformers Magazine (transformers-magazine.com)

***
Before Elihu Thomson, an electrical engineer working for Westinghouse in the US, patented the use of mineral oil in transformers in 1887, the burgeoning transformer industry had a major problem to solve. As transformers operate, energy losses occur, generating heat. As higher loads are applied, losses increase exponentially, rapidly raising temperatures in a transformer’s core and windings. Without adequate cooling, this heat prematurely ages the transformer, ultimately leading to equipment failure. At the time, the only insulating material used was air, but because these first transformers generated high amounts of losses, they were quickly limited in size by the rapid generation of heat that air failed to properly dissipate. Any attempts at larger devices would fail. Once Elihu Thomson identified oil as a readily available solution, the history of oil as an insulating medium began. Today, several billion liters of mineral oil are used in electrical equipment worldwide.
***

I used mineral oil to cool the overclocked computer I built two years ago. 


The white mineral oil jug is visible in the background. The copper BBs and pennies in the oil pan act as heat sinks. In retrospect, I could have gotten even better cooling by lifting up the corners of the pan a few inches to get airflow under it. An even better set-up would have been to put a layer of aluminum foil on the table, set a damp towel on that, and then put the oil pan on top of the towel. That would have gotten me cooling from radiation and evaporation. 

NSA has a water-cooled computer complex in Utah. Yes, the best idea their engineers had was to use evaporation cooling in a desert. That's a poor design to say the least.

***
The Utah Data Center (UDC), also known as the Intelligence Community Comprehensive National Cybersecurity Initiative Data Center,[1] is a data storage facility for the United States Intelligence Community that is designed to store data estimated to be on the order of exabytes or larger.[2]
...
The completed facility is expected to require 65 megawatts of electricity, costing about $40 million per year.[6][19] Given its open-evaporation-based cooling system, the facility is expected to use 1.7 million US gal (6,400 m3) of water per day.[24]
***

There's potential to save enormous amounts of power by overclocking. When one CPU can do the work of hundreds or thousands, computers became vastly smaller, cheaper, and more powerful. Computers are about as small and cheap as they're ever going to be, and advances in software are few and far between. Thus, the only avenue of improvement left is heat transfer. 

There is a Japanese supercomputer called Tsubame KFC. The KFC part stands for Kepler Fluid Cooling. Like the computer I built, the nodes of the supercomputer are immersed in mineral oil. 

Early efforts at liquid-cooled computers had mixed results:

***
Ahead of overview of TSUBAME-KFC's cooling technology with warm liquid (oil) submersion, we discuss the cooling methodologies; While submersion cooling has been deployed in the past in machines such as the Cray-2, the Florinate coolant utilized was extremely expensive, and moreover evaporated at low temperature of 56 degrees Celsius, and in fact the vapor was collected to be re-condensed, requiring airtight packaging
***

My oil-cooled computer never got above 40 degrees C even during a CPU stress test. Also, one gallon of the mineral oil I used costs about $29. 

These guys broke the record for overclocking this year. They used liquid nitrogen as a coolant. Liquid nitrogen is dangerous, expensive, and while it is very cold, its heat transfer properties are poor because it evaporates so quickly. 9 GHz is impressive, but they could have gotten even better performance with mineral oil. I overclocked my oil-cooled computer to 5 GHz. That was the maximum I found. Higher than that, and I'd get a kernel panic when trying to boot up. 

I mention all this because rather than spend hundreds of dollars on a computer I don't need to test a concept that's already been proven, I thought it would be better to simply write an article about how to build a machine that combined all these useful ideas.

So here's how it should be done: Make a cluster of the desired size using Intel 13900K chips. Submerge the CPUs in mineral oil. Overclock the chips in 1 GHz implements until 90% of the available power supply is used. A regular US household outlet offers about 1500 W. That's enough power to get to at least 90 GHz. The 9 GHz crew above used 125 W to get there, so 90 GHz would need about 1250 W.

Microsoft did something similar a few years back when then submerged a data center in a waterproof shipping container:

***

Back in 2018, Microsoft sunk an entire data center to the bottom of the Scottish sea, plunging 864 servers and 27.6 petabytes of storage 117 feet deep in the ocean. Today, the company has reported that its latest experiment was a success, revealing findings that show that the idea of an underwater data center is actually a pretty good one.

***

Microsoft’s underwater server experiment resurfaces after two years - The Verge

Good job, Microsoft. Next time, fill the container with mineral oil and then partially submerge it in cold water. Lake Michigan would be best as it has the coldest water in the lower 48. Mount the shipping container vertically in water, like the one on the left in the pic below:



Thursday, November 16, 2023

The Mpemba Effect - A Salute to an Unsung Tanzanian Scientist

 ***

Erasto Bartholomeo Mpemba (1950–2023)[note 1] was a Tanzanian game warden who, as a schoolboy, discovered the eponymously named Mpemba effect, a paradoxical phenomenon in which hot water freezes faster than cold water under certain conditions; this effect had been observed previously by Aristotle, Francis Bacon, and René Descartes.

He discovered the phenomenon at Magamba Secondary School in 1963 while preparing ice cream to earn pocket-money.[3] Due to lack of time, he skipped the cooling phase when preparing the ice cream and immediately put it into the freezer; unexpectedly, his milk mixture froze faster than that of his classmates.[2] His physics teacher at the time told him that his observation was clearly not possible.[2] A few years later, the head of Mpemba's school invited British physicist Denis Osborne (1932-2014) from the University of Dar es Salaam to give a guest lecture on his work.[4] At the end of the presentation, Mpemba asked the question that had been bothering him for so long: “If you take two beakers with equal volumes of water, one at 35°C and the other at 100°C, and put them into a refrigerator, the one that started at 100°C freezes first. Why?”[2] Teachers and classmates present thought the claim absurd and mocked Mpemba for the question. Osborne was also caught off guard, but was later able to prove experimentally the correctness of Mpemba's observations.[2][4] In 1969, during Mpemba's studies at the College of African Wildlife Management near Moshi, a paper that he and Osborne had written on the phenomenon was published.[5]

***

A lovely story that shows the importance of perseverance and having an open mind. Everyone who pays attention and asks questions can make a scientific discovery. 

Tuesday, November 14, 2023

Proof of the Existence of One-Way Functions and a True Random Number Generator (Solution to P versus NP problem)

Here is probably the smartest idea I'll ever have. 

First, take some time to watch this video (skip to the 15:10 mark):


Now look at this graph:


It's an asymmetric oscillation with one hump. If you iterate it, you get random numbers in the range of 100 to 200. It's a true random number generator and thus a one-way function. Furthermore, it describes a family of one-way functions. Any composite of trigonometric, logarithmic, and exponential functions will produce something similar. Of course, the initial value must be in the domain of ln(x) and produce an f(x) > 1. Else, the function approaches zero upon iteration. 

Thus, a general equation for one-way functions and random number generators is:

f(x) = a*(b*sin(c*x) + d*ln(e*x))^f

Where a, b, c, d, e, and f are real numbers. 

Note that when f(x) = r*(1-x) is iterated, chaos occurs when r = 3.759816

https://youtu.be/ovJcsL7vyrk?si=y8JO21psWtpq2TYS&t=312

***

In computer science, a one-way function is a function that is easy to compute on every input, but hard to invert given the image of a random input. Here, "easy" and "hard" are to be understood in the sense of computational complexity theory, specifically the theory of polynomial time problems.

***

***

The existence of such one-way functions is still an open conjecture. Their existence would prove that the complexity classes P and NP are not equal, thus resolving the foremost unsolved question of theoretical computer science.[1]: ex. 2.2, page 70  The converse is not known to be true, i.e. the existence of a proof that P≠NP would not directly imply the existence of one-way functions.[2]

***

Cool. I solved the P = NP problem too. You're terminated, fucker.

***

Although the P versus NP problem was formally defined in 1971, there were previous inklings of the problems involved, the difficulty of proof, and the potential consequences. In 1955, mathematician John Nash wrote a letter to the NSA, in which he speculated that cracking a sufficiently complex code would require time exponential in the length of the key.[5] If proved (and Nash was suitably skeptical), this would imply what is now called P ≠ NP, since a proposed key can easily be verified in polynomial time. Another mention of the underlying problem occurred in a 1956 letter written by Kurt Gödel to John von Neumann. Gödel asked whether theorem-proving (now known to be co-NP-complete) could be solved in quadratic or linear time,[6] and pointed out one of the most important consequences—that if so, then the discovery of mathematical proofs could be automated.

***

A New Way to Approximate Pi

 Archimedes was able to bracket the value of pi by constructing 96-sided polygons inside and outside a triangle. Since the diameter of the circle and the perimeters of the polygons were known, he was able to conclude that pi must be between 

***

In the 3rd century BCE, Archimedes proved the sharp inequalities 223⁄71 < Ï€ < 22⁄7, by means of regular 96-gons (accuracies of 2·10−4 and 4·10−4, respectively).

***

My method of approximating pi assumes that a circle is a polygon with an infinite number of sides. In that case, pi is equal to n*cos(a/2), where n is the number of sides of a regular polygon and a is the measure of one of its interior angles as given by the formula (n -2)*180/n. 

For n = 100,000, we get:

100,000*cos((100,000-2)*180/(100,000*2)) = 3.14159265

Those are indeed the first 9 digits of pi. My method probably has some computational advantages over other ways, though since pi has been calculated to many digits already, it's not particularly important.

For n = 1,000,000, I get pi = 3.1415926356

For n = 10,000,000, I get pi = 3.1415926533

The first 11 digits of pi are 3.1415926535.

Sunday, November 12, 2023

Comparison of Polypeptide and Glycopeptide Antibiotics

 


Below are two different diagrams of bacitracin. Not sure which one has more accurate bond angles. I rarely see molecules form big circles.




Wikipedia says:

***
Cyclic peptides are polypeptide chains which contain a circular sequence of bonds.[1] This can be through a connection between the amino and carboxyl ends of the peptide, for example in cyclosporin; a connection between the amino end and a side chain, for example in bacitracin; the carboxyl end and a side chain, for example in colistin...
***

Colistin is a polymyxin, but since it was mentioned as being a cyclic peptide too, I'll add it below.


Amanitin has an indole core. That's first one I've seen so far. 





***
Teicoplanin is an antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and Enterococcus faecalis. It is a semisynthetic glycopeptide antibiotic with a spectrum of activity similar to vancomycin. Its mechanism of action is to inhibit bacterial cell wall synthesis.[2]
...
Its strength is considered to be due to the length of the hydrocarbon chain.[4]
***

I'm not sure why the length of the hydrocarbon chain would matter. Then again, I only had two semesters of organic chemistry in college. Checking the reference, I got this:

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Teicoplanin is the only glycopeptide antibiotic not to dimerise, but its potency is believed to come from its long hydrocarbon chain. This anchors the antibiotic to the cell membrane from where it can more effectively inhibit cell wall synthesis.
***

I wonder how that hypothesis about the length of the carbon chain could be tested. If it could be made to dimerize, would that molecule also be medicinal?



This one has a good breakdown of what are effectively the antibiotic's functional groups. 


Like teicloplanin, telavancin has a long hydrocarbon chain coming off a nitrogen.  


Ramoplanin also has a hydrocarbon chain coming off a nitrogen, though the chain has carbon-carbon double bonds and a keto group like teicoplanin.  

These last three are chemotherapy drugs.




Pingyangmycin is interesting because it is also a glycopeptide but is used to treat cancer rather than bacterial infections. 



How Many Countries Are De Facto One-Party States? (About 110 out of 194)

The de jure one-party states are China, Cuba, Eritrea, Laos, North Korea, and Vietnam. So that's five.

Some of the larger de-facto ones are Russia, Japan, and Mexico. Some of the smaller ones are Singapore, Angola, Republic of Congo, Equitorial Guinea, and Rwanda. That's eight more, so 13 total.

Most monarchies are effectively one-party states, with the royal family being the ruling party. That includes Saudi Arabia, Qatar, UAE, Oman, Bahrain, Kuwait, Jordan, Brunei, Eswatini, and Morocco. That's another 10, so 23 total. 

There are countries like Venezuela, Turkmenistan, Belarus, and Syria, which are dictatorships, so four more. Then there are countries like Egypt and Burma which are run by the military. We're up to 29 now.  

Iran's ruling mullahs have been in charge since 1979.  The Turkish AK Party has been in charge since 2002. The CCM party in Tanzania has ruled since 1977. 

The Taliban are in control of Afghanistan. Thailand spent long stretches under military rule. So that's 34.

I could keep going, but fortunately, Freedom in the World made a list already. 83 of 194 countries on it are not electoral democracies. The good news is another 84 countries are electoral democracies which are rated as "free". The remaining 27 are partly free. 

I do not think one-party states are inevitable, but they are a common outcome. Once a country slides into one-party rule, it tends to stay there. They are also not always bad places to live, as Japan proves. 

On the whole, it seems economic freedom is more important than political freedom to well-being. Economic freedom tends to promote political freedom. 


Comparison of Azole Medicines

 The simplest one (probably) is used to treat methanol poisoning.



A five-sided, two-nitrogen ring of a different sort here:


A more common antifungal appears below. The clover shape of the benzene and azole rings is something I don't see often. 


Another azole medicine I found with chlorine is below.



There are similarities between itraconazole, an antifungal and sonidegib, an anticancer drug. Sonidegib is also a hedgehog signaling pathway inhibitor. Another fun fact:

***
Sonic hedgehog protein (SHH) is encoded for by the SHH gene.[5] The protein is named after the character Sonic the Hedgehog.
***

Further down the Wikipedia hole, I found:

***
The function of the hedgehog segment polarity gene has been studied for influence on the normally polarized distribution of larval cuticular denticles as well as features on adult appendages such as legs and antennae.[7] Rather than the normal pattern of denticles, hedgehog mutant larvae tend to have "solid lawns" of denticles (Figure 1). The appearance of the stubby and "hairy" larvae inspired the name 'hedgehog'.
***

It's interesting that heartburn medicine is the result of studying how butterfly larvae develop. It's impossible to predict what scientific knowledge be useful. 



Two anti-parasitic worm medicines, both with heterocyclic rings. 




The above are truncated forms of a proton pump inhibitor. Note the heterocyclic part. Other PPI drugs appear below. Some treat acid reflux disease. Others kill parasitic worms. 




Here are two with sulfur.




And here are two with fluorine:



Comparison of Antiviral Medicines - Are There Pyrimidine-based Antivirals?

Some have core based on purine, such as aciclovir and entecavir. Several examples are shown below. It's interesting to note that antivirals in this group are structurally similar to the nucleotides adenine and guanine. That implies there are antivirals based similar to cytosine and thymine, which are pyrimidines. 











Ribavirin has only one nitrogen ring. Atazanavir has one nitrogen ring of a different sort, as does lamivudine. 











Nevirapine and its cousins have a triple ring structure. Note the cyclopropyl group, also found in other antivirals. 


Oseltamivir has no ring nitrogen atoms. 




Daclatasvir is a rare symmetrical antiviral. In general, it is rare for any medicine to be symmetrical. It has two imidazole rings. Ombitasvir is symmetrical and like daclatasvir is belongs to the NS5A inhibitor group. Velpatasvir has two imidazole rings, but is asymmetrical. 







Here are some with fluorine. Like telaprevir, efavirenz also has a cyclopropyl group. 









Darunavir has sulfur, as does ritonavir in ring (thiazole) form. 




Protease inhibitors form a family of antivirals. Many contain sulfur, fluorine, or phosphorus. Asunprevir contains two cyclopropyl groups.







This combo has a very high cure rate against HepC and belongs to the NS5A inhibitor group. 



Telaprevir is an antiviral containing pyrazine (not pyrimidine) as a functional group. 






To summarize, most antivirals are either based on purine or are protease inhibitors. Here I will note I only has two semesters of organic chemistry in college in the course of earning my BS in chemical engineering. I got an A in the first semester and a C in the second semester.